Baboon syndrome

SDRIFE

Symmetrical Drug-Related Intertriginous (buttock and groin folds) and Flexural (other folds) Erythema (redness)

LASER TISSUE INTERACTION

The role of lasers in dermatology has increased dramatically over the past two decades. A fundamental understanding of laser-tissue interactions is vital for the proper and appropriate use in clinical practice.

1. Light can interact with tissue in four key ways:

• Transmission

• Reflection

• Scattering

• Absorption

2. Selective photothermolysis

• The theory of selective photothermolysis refers to laser energy absorption by a target chromophore without significant thermal damage to surrounding tissue.

• To achieve selective photothermolysis, 3 main factors:
• A. The laser must produce a beam of light with a wavelength preferentially absorbed by the chromophore in the lesion.
• B. The pulse duration of the laser beam must be shorter than the thermal relaxation time of the chromophore to prevent the spread of thermal energy beyond the targeted chromophore.
• C. The energy delivered to the site (fluence) must be high enough to destroy the chromophore within the pulse duration.

Classification of photodermatoses

Photodermatoses ass diff age group

Photogenodermatoses

ARA criteria for SLE

The ARA published criteria for the diagnosis of lupus in 1982. These criteria serve as a guide to information that is useful on history and physical examination. The following are criteria for the classification of systemic lupus erythematosus (SLE).

1. Malar rash
2. Discoid lupus erythematosus lesions
3. Photosensitivity (by history or observation)
4. Oral ulcers, usually painless, observed by physician
5. Arthritis-nonerosive, involving two or more joints
6. Serositis-pleuritis or pericarditis
7. Renal disorder-proteinuria (>500 mg/day) or cellular casts
8. Central nervous system disorder-seizures or psychosis (absence of known cause)
9. Hematologic disorder-hemolytic anemia, leukopenia (<4000/mm2) or thrombocytopenia (< 100,000/mm2)
10. Immunologic disorder-positive LE prep, abnormal titers of antinative (n) DNA, and anti-Sm, false-positive VDRL
11. Antinuclear antibody

If four or more criteria are present serially or simultaneously during any period of observation, the patient is considered to have SLE.

Shingles Vaccine Recommended for All Older Adults

The Centers for Disease Control and Prevention is now recommending that all adults age 60 and older receive a dose of the zoster vaccine (Zostavax), even if they have had shingles previously.

MMWR 2008

In subjects age 60 and older, use of Zostavax was found to reduce the overall occurrence of herpes zoster by roughly 50%.

For people in their 60s, the risk reduction was 64%.