Finally, Evidence That Sunscreen Delivers

Primary melanomas developed less often with daily, rather than discretionary, sunscreen use.

Published in Journal Watch Dermatology March 11, 2011

Citation:
Green AC et al. Reduced melanoma after regular sunscreen use: Randomized trial follow-up. J Clin Oncol 2011 Jan 20; 29:257.
Gimotty PA and Glanz K. Sunscreen and melanoma: What is the evidence? J Clin Oncol 2011 Jan 20; 29:249.

Comment:

This large, community-based sunscreen trial is likely the last of its scope.

The findings won't change sunscreen recommendations but do provide clear support for its use.

Sunscreen alone is insufficient to eliminate melanoma risk, and the effects of all-form sun protection on melanoma mortality are unknown. Also, these findings leave unaddressed sunscreen use in less-sunny locations and in populations with other skin tones.

Nevertheless, this carefully executed and ambitious study is commendable. The same trial has already shown reduced squamous cell carcinoma risk, so its clinical implications are compelling.

One could question the borderline significance of the risk reductions, or note that the incidence of melanoma versus non-melanoma skin cancers undermined the study's power from the beginning, but the author of an accompanying editorial carefully outlines the statistical rigor of this trial.